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β-内啡肽(β-EP)来源于前阿黑皮素原(POMC)系统,主要分布于下丘脑和垂体,血浆中的β-EP主要由垂体释放而来。动物实验表明,在缺氧、休克、疼痛等各种应激状态下,β-EP可大量释放,严重抑制呼吸。本文采用放免法测定肺心病呼衰患者血浆的β-EP变化,观察其在发病中的作用,以及应用纳络酮的疗效。 1.一般资料。肺心病组36例,男24例,女12例;年龄49～78岁,平均64.7岁;病程为10～36年,平均24.8年;其中呼衰21例,非呼衰者15例。对照组20例,均为体检正常者,其性别、年龄与肺心病组相仿。
β-EP is derived from pre-pro-melanocortin (POMC) system and mainly distributed in hypothalamus and pituitary. β-EP in plasma is mainly released from pituitary. Animal experiments show that, in hypoxia, shock, pain and other stress conditions, β-EP can be a large number of release, severe inhibition of respiration. In this paper, radioimmunoassay determination of plasma in patients with respiratory failure of pulmonary heart disease, β-EP changes observed its role in the pathogenesis, as well as the application of naloxone efficacy. General information Pulmonary heart disease in 36 cases, 24 males and 12 females; aged 49 to 78 years, mean 64.7 years; duration of 10 to 36 years, an average of 24.8 years; of which 21 cases of respiratory failure, non-respiratory failure in 15 cases. Control group of 20 patients were normal physical examination, their gender, age and pulmonary heart disease group similar.