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研究高强度聚焦超声(HIFU)在组织内能量的存积规律及表达方式.用JC型聚焦超声肿瘤治疗系统将超声波聚焦,辐照离体的牛肝、肾、肌肉组织和活体的猪肝、肾、肌肉组织,观察单点凝固性坏死的形成和体积变化规律.无论离体、活体组织的凝固性坏死点的形态和体积均不同于声学焦域;如果声强为7×103～25.4×103W/cm2,辐照时间为0～20s,则凝固性坏死点的体积为0～2000 mm3;同一剂量辐照下,不同组织结构、不同功能状态、不同组织深度所形成的单点凝固性坏死的体积不同.整块肿瘤的凝固是由一个一个小点状的凝固性坏死组合而成.把这个点状的凝固性坏死范围叫做HIFU的生物学焦域.生物学焦域是HIFU切除肿瘤的基本单元.它是声学焦域、声强、辐照时间、治疗深度、组织结构及功能状态的函数.
To study the energy accumulation and expression pattern of high-intensity focused ultrasound (HIFU) in tissue.Using JC focused ultrasound tumor treatment system to focus the ultrasound, the liver, kidney, muscle tissue and live liver, Kidney and muscle tissue.We observed the formation and volume changes of single point coagulation necrosis.It is different from acousto-focal field in the shape and volume of coagulation necrosis of living tissue both in vitro and in vivo.If the sound intensity is 7 × 103 ~ 25.4 × 103W / cm2, irradiation time is 0 ~ 20s, then the volume of coagulation necrosis point is 0 ~ 2000mm3; under the same dose of irradiation, different tissues, different functional status, different depth of the formation of single point coagulation necrosis Of the volume of the solidification of the entire tumor is a combination of a small dot-like coagulation necrosis .The dot-like coagulation necrosis is called biological focal region HIFU biological focal region is HIFU resection of the tumor The basic unit, which is a function of acoustical focal region, sound intensity, irradiation time, depth of treatment, tissue structure and functional status.