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致炎细胞因子会引起并加重炎症级联反应,在组织损伤中起重要作用。炎症局部纤溶酶原被纤溶酶原激活剂(PA)活化成纤溶酶,纤溶酶可致纤维蛋白溶解,引起组织损伤。目前就牙髓根尖周疾病中通过组织型-PA(t-PA)蛋白水解途径致组织损伤的机制及致炎细胞因子的作用研究较少。本研究目的是确定在培养的人牙髓细胞、牙龈成纤维细胞中致炎细胞因子IL-1α和TNE-α对PA/纤维溶酶系统的作用。 材料和方法 拔除健康的阻生第三磨牙,将
Inflammatory cytokines cause and exacerbate the inflammatory cascade and play an important role in tissue damage. Local inflammatory plasminogen is activated by plasminogen activator (PA) into plasmin, plasmin can cause fibrinolysis, causing tissue damage. At present, there are few studies on the mechanism of tissue damage induced by tissue-PA (t-PA) proteolytic pathway and the effect of proinflammatory cytokines in periapical periodontal disease. The aim of this study was to determine the effect of pro-inflammatory cytokines IL-1α and TNE-α on the PA / plasmin system in cultured human dental pulp cells and gingival fibroblasts. MATERIALS AND METHODS Removal of healthy impacted third molars, will