脆性糖尿病又称不稳定型糖尿病,临床特点表现为血糖波动幅度大,病情极不稳定,酮症酸中毒和低血糖反复交替发生,病死率高,是治疗糖尿病的一大难题。本病例经过个体化的治疗配合血糖监测,最终使得患者病情得到稳定。1病历资料患者,女性,32岁,10年前因受凉后出现恶心、呕吐、意识模糊在当地医院就诊,化验血糖26.3mmol/L,尿酮体4+,尿糖4+。入院后化验胰岛细胞抗体和胰岛素自身抗体均为阳 Brittle diabetes, also known as unstable diabetes, clinical manifestations of large fluctuations in blood glucose, the disease is extremely unstable, ketoacidosis and hypoglycemia repeated alternately, mortality is a major problem in the treatment of diabetes. This case after individualized treatment with blood glucose monitoring, and ultimately make the patient’s condition stabilized. A patient data, female, 32 years old, 10 years ago due to cold nausea, vomiting, confusion in the local hospital for treatment, blood glucose 26.3mmol / L, urinary ketone body 4 +, urine 4+. After admission, test islet cell antibodies and insulin autoantibodies are positive