目的　了解注射相关锐器伤的危险因素 ,提供安全注射指导。方法　采用现况调查和1∶1配比研究 ,对广州市 13所医院 3 0 10名护士锐器伤的流行特征及危险因素进行分析。结果87.5 %的护士有过锐器伤的经历 ,锐器伤的月发生率为 3 7.6% ,发生密度为每人每月 0 .84次。锐器伤的月发生率与职称相关 ,锐器伤的经历与护龄、婚姻状况、雇用形式、职称有关。 66%的锐器伤集中发生在白天 ,5 1%的锐器伤发生在治疗室。logistic多元回归分析显示 ,锐器伤发生的危险因素除与接触针头的频率、操作者的知识、认知、个性等有关外 ,还与注射前掰安瓿不使用纱布、注射中工作空间拥挤噪杂、护理对象有较多不合作病人、注射后有回套针帽的习惯等因素有关。结论　调查人群中锐器伤的发生非常普遍 ,其流行特征与危险因素的分布不同于国外研究结论。研究结果可为国内医院感染控制部门及卫生行政部门制订安全注射的政策提供参考依据 Objectives To understand the risk factors associated with sharps injuries related to injection and to provide safe injection guidance. Methods Based on the status quo survey and the 1: 1 ratio study, the prevalence and risk factors of sharp injuries of 3 0 10 nurses in 13 hospitals in Guangzhou were analyzed. Results 87.5% of the nurses had experience of sharp injury. The monthly incidence of sharp injuries was 3 7.6% and the occurrence density was 0.84 times per month. The monthly incidence of sharp injuries related to titles, sharp injuries experience and care, marital status, employment forms, titles related. Sixty-six percent of sharp injuries occur concentrated during the day and 51% of sharp injuries occur in the treatment room. Logistic multivariate regression analysis showed that the risk factors for sharp weapon injury in addition to the contact needle frequency, the operator’s knowledge, cognition, personality, etc., but also with the pre-injection ampoules do not use breaking gauze, injections in the work space crowded noise , The object of care are more non-cooperative patients, after the injection of a needle cap and other factors related to the habit. Conclusions The occurrence of sharp injuries in the survey population is very common. The distribution of epidemiological characteristics and risk factors are different from those of foreign studies. The results of this study can provide a reference for the development of safety injections policies of infection control departments and health administrative departments of domestic hospitals