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耳毒性药物和噪声在耳蜗、前庭病理性破坏中占有重要地位。声响负荷与抗生素耳毒性联合作用则对内耳的影响特别大,然而,噪声增强抗生素毒性作用的机制仍然不明。为此,著者研究了噪声对链霉素在内耳结构含量分配的影响。应用组织自动放射摄影术追踪观察注入动物体内的标记物,即以~(35)S标记的放射性链霉素硫酸盐,按每公斤体重50毫居里的剂量(200000/kg)注入实验动物的腹腔内。用强度为100dB,频率为2870～5740赫的窄带噪声进行刺激,实验动物为45只白鼠和15只豚鼠。分两个实验组,第一组动物声音刺激持续6小时后立即杀死,而在噪声持续达3小时时注入放射性链霉素。第二组实验动物每天接受6小时的噪声刺激共5天,也是在实验终了前3小时注入链霉素。对照组的动物注入链霉素而不进行噪声刺激,在注射后3小时杀
Ototoxic drugs and noise play an important role in cochlear and vestibular pathology. The combined effects of acoustic load and antibiotic ototoxicity have a particularly large effect on the inner ear, however, the mechanism by which noise increases the toxic effects of antibiotics remains unclear. To this end, the authors studied the effect of noise on streptomycin content distribution in the inner ear. Autoimmune radiography was used to observe the amount of radioactive streptomycin sulfate labeled with ~ (35) S injected into animals at a dose of 50 milligrams per kilogram of body weight (200 000 / kg) Intraperitoneal. Excitation was performed with a narrowband noise of 100 dB at a frequency of 2870-5740 Hz. The experimental animals were 45 rats and 15 guinea pigs. Divided into two experimental groups, the first group of animals were killed immediately after 6 hours of sound stimulation, while radioactive streptomycin was injected at a noise level of up to 3 hours. The second group of animals received a noise stimulus of 6 hours a day for 5 days, also streptomycin 3 hours prior to the end of the experiment. Animals in the control group were infused with streptomycin without noise stimulation and killed 3 hours after injection