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目的 探讨研究雌激素受体 (ER)水平对青年乳腺癌预后的影响及术后治疗的指导作用。方法 根据ER水平 ,将收治的 78例 35岁以下青年女性原发乳腺癌分成ER(+)和ER(- )两组。按Kaplan Meier法计算。并按时序检验比较两组生存曲线的趋势。结果 ER(+)组 4 8例 ,中位随访时间 95个月 (13～ 12 0月 ) ,13例出现复发转移 ,复发转移率为 2 7 1% (13 4 8)。ER(- )组 30例 ,中位随访时间为 6 5个月 (1～ 12 0月 ) ,16例出现复发转移 ,复发转移率为 53 3% (16 30 )。ER(+)组术后复发转移率明显低于ER(- )组 (P <0 0 5)。结论 ER是青年女性乳腺癌术后的一个重要预后参考因素。ER(+)组 10年无病生存率明显高于ER(- )组。
Objective To investigate the effect of estrogen receptor (ER) level on the prognosis of young breast cancer and the guiding role of postoperative treatment. Methods Based on the ER level, 78 cases of young women under 35 years of age who were admitted to primary breast cancer were divided into ER (+) and ER (-) groups. Calculated by Kaplan Meier method. And according to the time series test to compare the survival curve of the two groups. Results In the ER(+) group, there were 48 cases. The median follow-up time was 95 months (13 to 12 months). 13 cases had recurrence and metastasis, and the recurrence and metastasis rate was 27.11% (134.8). In the ER (-) group, 30 patients had a median follow-up of 65 months (1 to 12 months). Recurrence and metastasis occurred in 16 patients. The recurrence and metastasis rate was 53 3% (16 30 ). The rate of postoperative recurrence and metastasis in the ER(+) group was significantly lower than that in the ER(-) group (P < 0.05). Conclusion ER is an important prognostic factor for postoperative breast cancer in young women. The 10-year disease-free survival rate in the ER(+) group was significantly higher than that in the ER(-) group.