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心肌药理性预适应是根据心肌缺血预适应机理，通过模拟心肌缺血预适应方法，研究用药物激发或模拟机体内源性保护物质呈现的保护心脏作用。根据作用机理的不同，预适应药物可分为受体依赖性和非受体依赖性二种类型。与Ｇ蛋白偶联的受体激动剂如腺苷（Ａ１，Ａ３受体）、缓激肽（Ｂ２受体）、降钙素基因相关肽（ＣＧＲＰ受体）、去氧肾上腺素和去甲肾上腺素（α１受体）、吗啡（阿片受体）等以及ＡＴＰ敏感性钾通道开放剂、蛋白激酶Ｃ（ＰＫＣ）激活剂、血管紧张素转换酶抑制剂、一磷酸类脂Ａ等都具有药物预适应样保护心脏作用。药理性预适应是正在研究的保护心脏的新途径
Cardiac pharmacological preconditioning is based on myocardial ischemic preconditioning mechanism, by simulating myocardial ischemic preconditioning method to study the use of drugs to stimulate or simulate the endogenous protective substances present in the body to protect the heart. According to the different mechanism of action, pre-adapted drugs can be divided into two types of receptor-dependent and non-receptor-dependent. Receptor agonists conjugated to G proteins such as adenosine (A1, A3 receptor), bradykinin (B2 receptor), calcitonin gene related peptide (CGRP receptor), phenylephrine and noradrenal (Α1 receptor), morphine (opioid receptor) and the like as well as ATP-sensitive potassium channel opener, protein kinase C (PKC) activator, angiotensin converting enzyme inhibitor, monophosphate lipid A, Adapt to protect the heart function. Pharmacological preconditioning is a new way of protecting the heart that is under study