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我们对17例ALL 58次HD-MTX治疗,出现的副作用及处理进行了总结分析,认为:(1)副作用以呕吐、发热及药物性肝炎多见;(2)发热可能与MTX直接脑毒性有关;(3)药物性肝损害表现为GPT增高,可于短期内恢复;(4)局部应用0.1g/L四氢叶酸钙可减轻口腔及肛周溃疡的发生。
We analyzed the side effects and treatments of 17 HD-MTX treatments in 58 ALL patients, and concluded that: (1) side effects were common with vomiting, fever and drug-induced hepatitis; (2) fever may be directly related to MTX ; (3) drug-induced liver damage showed GPT increased in the short term recovery; (4) topical application of 0.1g / L calcium leucovorin can reduce the occurrence of oral and perianal ulcers.