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目的:探讨丹溪治湿痰方治疗抗精神病药物所致闭经的疗效。方法:选取佛山市第三人民医院2015年7月至2015年12月因服抗精神病药物引起闭经的女性精神分裂症患者60例,随机分为观察组和对照组,各30例。两组患者在服用抗精神病药物的同时,观察组给予丹溪治湿痰方治疗,对照组给予阿立哌唑5 mg/d口服治疗。治疗前、后测定催乳素(PRL)水平,对两组患者治疗后的疗效进行评定。结果:两组患者总完成率为100%;观察组总有效率为93.33%(28/30);对照组总有效率为86.67%(26/30),观察组优于对照组,但两组比较,差异无统计学意义(P>0.05)。两组患者治疗后PRL水平均下降,与治疗前比较,差异有统计学意义(P<0.01),治疗后组间比较,差异无统计学意义(P>0.05)。结论:丹溪治湿痰方与阿立哌唑均能降低抗精神病药物所致闭经患者的PRL水平,且疗效相当。
Objective: To explore the effect of Danxi Zhitan Recipe in treating amenorrhea induced by antipsychotics. Methods: A total of 60 female schizophrenic patients with amenorrhea caused by antipsychotics from July 2015 to December 2015 in Foshan Third People’s Hospital were randomly divided into observation group and control group, with 30 cases in each group. Two groups of patients taking antipsychotic drugs at the same time, the observation group was treated Danxi Zhitan Fang treatment, the control group given aripiprazole 5 mg / d oral treatment. Prolactin (PRL) levels were measured before and after treatment, and the efficacy of treatment was evaluated in both groups. The total effective rate was 93.33% (28/30) in the observation group and 86.67% (26/30) in the control group. The observation group was superior to the control group, but both groups The difference was not statistically significant (P> 0.05). PRL levels in both groups decreased after treatment, compared with before treatment, the difference was statistically significant (P <0.01), after treatment there was no significant difference between the two groups (P> 0.05). Conclusion: Danxi Zhitan Fang and aripiprazole can reduce the antipsychotic-induced amenorrhea in patients with PRL levels, and the effect is quite.