目的:研究并分析治疗高龄重症社区获得性肺炎患者时使用有创-无创序贯性机械通气的效果。方法:收集高龄重症社区获得性肺炎患者共82例,根据随机化分组原则分为对照组(41例)和观察组(41例),对照组接受常规机械通气,观察组接受有创-无创序贯性机械通气,将两组患者机械通气时间、死亡率进行观察和对比。结果:观察组机械通气时间、死亡率与对照组相比,差异显著,P均<0.05。结论:在高龄重症社区获得性肺炎患者的治疗过程中,有创-无创序贯性机械通气能够使患者获得更佳疗效,降低患者的病死率,并促进其康复,值得推广应用。 OBJECTIVE: To study and analyze the use of invasive-non-invasive sequential mechanical ventilation in the treatment of elderly patients with severe community-acquired pneumonia. Methods: A total of 82 elderly patients with severe community-acquired pneumonia were collected and divided into control group (41 cases) and observation group (41 cases) according to the principle of randomization. The control group received routine mechanical ventilation, and the observation group received invasive-noninvasive Mechanical ventilation, the two groups of patients with mechanical ventilation time and mortality were observed and compared. Results: Compared with the control group, the difference of mechanical ventilation time and death rate in the observation group was significant (P <0.05). Conclusions: In the treatment of elderly patients with severe community-acquired pneumonia, invasive and non-invasive sequential mechanical ventilation can make the patients get better efficacy, reduce the patient’s mortality and promote their rehabilitation, which is worth popularizing and applying.