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目的:研究应用骨源性碱性磷酸酶(BALP),判定长期吸入糖皮质激素的支气管哮喘患儿是否出现骨代谢异常。方法:(1)应用骨源性碱性磷酸酶BALP试剂盒对使用吸入布地奈德治疗支气管哮喘的157例1～3岁患儿进行检测。(2)分别在使用气雾剂前、6个月、12个月各采血一次,同时随机抽取同期儿科体检儿童做正常对照组。以BALP≥250u/L为异常界线值,或BALP增高变化超过50u/L为异常。结果:2组儿童的BALP值异常率差异无显著性。结论:BALP检测作为一种经济简便的生化检查手段,可用于哮喘儿童治疗中激素副作用的监测指标。
OBJECTIVE: To study the use of bone alkaline phosphatase (BALP) in determining the presence or absence of abnormal bone metabolism in asthmatic children with long-term inhaled corticosteroids. Methods: (1) 157 cases of children aged 1 to 3 years old with bronchial asthma treated with inhaled budesonide were tested with the bone alkaline phosphatase BALP kit. (2) Blood samples were taken at 6 months and 12 months before the use of aerosol respectively. At the same time, children in the same period were randomly selected as normal control group. To BALP ≥ 250u / L for the abnormal boundary value, or increased BALP changes more than 50u / L is abnormal. Results: There was no significant difference in the abnormal rate of BALP in two groups of children. Conclusion: As a simple and economical biochemical examination, BALP test can be used to monitor the side effects of hormones in children with asthma.