由利什曼原虫引起的美洲皮肤利什曼病(NWCL)已成为中南美洲的一个重要健康问题。由细胞介导的免疫反应(CMI)对该病的免疫致病机制及疾病的愈合具有重要影响。HIV感染所产生的复杂的致病过程直接影响了有效免疫应答所必需的T细胞分化过程。有关艾滋病相关NWCL的报道中所述的利什曼病的某些异常临床表现可能与控制虫体播散的T细胞介导的免疫应答能力低 American Leishmaniasis (NWCL) caused by Leishmania has become an important health problem in Central and South America. Cell-mediated immune response (CMI) has a major impact on the immune pathogenesis and healing of the disease. The complex pathogenic processes resulting from HIV infection directly affect the T cell differentiation process necessary for an effective immune response. Some of the abnormal clinical manifestations of leishmaniasis reported in AIDS-related NWCL may be associated with the lower ability to control T cell-mediated immune responses disseminated by parasites