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本文对慢性活动性乙型肝炎病人的干扰素反应,干扰素抗病毒活性和免疫调节活性进行了研究,并和健康人作了配对比较。发现慢性活动性乙型肝炎病人α—干扰素反应能力显著减退,血清中出现抑制α—干扰素反应能力的因子和抑制α—干扰素抗病毒活性的因子;与α—干扰素相反,慢性活动乙型肝炎病人的刀豆素—A 活化淋巴细胞上清液的 r—干扰素在正常范围,抑制反应细胞刀豆素—A 增殖能力显著下降。认为慢性活动性乙型肝炎病人的干扰素功能状态,在病毒持续感染和免疫反应调节紊乱中起了重要的作用。并指出,使用大剂量、长疗程的外源性干扰素治疗慢性活动性乙型肝炎病人,具有一定的意义。
In this paper, interferon response, interferon antiviral activity and immunomodulatory activity in patients with chronic active hepatitis B were studied and compared with healthy controls. Found that patients with chronic active hepatitis B patients significantly decreased α-interferon response, serum α-interferon appears to inhibit the ability of the factor and inhibit the anti-α-interferon antiviral activity of the factor; and α-interferon in contrast to chronic activity Interferon-alpha in the concanavalin-A activated lymphocyte supernatant of hepatitis B patients is in the normal range, and the ability of repressing the proliferation of the concanavalin-A of the reaction cells is remarkably decreased. It is considered that the functional status of interferon in patients with chronic active hepatitis B plays an important role in the continuous virus infection and the regulation of immune response. And pointed out that the use of high-dose, long course of exogenous interferon treatment of chronic active hepatitis B patients, has a certain significance.