论文部分内容阅读
药物中挥发性成分的分析测定常需采用一定的样品前处理方法,在进行萃取、分离、纯化、富集后,再利用色谱法测定,以减少干扰成分及对色谱系统的损害等。传统的萃取纯化方法有液液萃取,如挥发油提取器提取法、水蒸气蒸馏萃取法、超声法和索氏提取法等,但这些方法均存在使用大量有机溶剂,提取时间长,提取效率低,操作步骤繁杂,暴露机会较多,易造成挥发成分损失,使样品的信息失真等缺点。近年来,固相萃取及固相微萃取技术虽然已用于药物中挥发性成分的含量测定,但其萃取装置的萃取头涂层种类少,价格昂贵,且使用寿命短,多次使用还存在交叉污染的问题。因此,需建立简单快速、密闭准确、选择性高、环境良好的样品前处理方法,用来分析检测药物中的挥发性成分。
Analysis and determination of volatile components in pharmaceuticals often require a certain amount of sample preparation, extraction, separation, purification, enrichment, and then use the chromatographic determination to reduce the interference components and the damage to the chromatographic system. The traditional extraction and purification methods are liquid-liquid extraction, such as volatile oil extractor extraction, steam distillation extraction, ultrasonic and Soxhlet extraction, etc., but these methods are the existence of large amounts of organic solvents, extraction time, extraction efficiency is low, Complex steps, more exposure opportunities, easy to cause loss of volatile components, the sample information distortion and other shortcomings. In recent years, solid-phase extraction and solid-phase microextraction has been used to determine the content of volatile components in medicine, but its extraction device has few kinds of extraction heads, is expensive, has short service life, and is used repeatedly Cross-contamination issues. Therefore, it is necessary to establish a simple, rapid, confined, selective, and environment-friendly sample preparation method for analysis of volatile components in pharmaceuticals.