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1969年Gastaut首先报道氯硝基安定(Ro5-4023,Clonazepam,Rivotril,Clo-nopin)治疗癫痫有效以及其抗惊厥作用比安定及硝基安定强5倍,以后通过广泛的临床实践发现其疗效较安定及硝基安定稳定。目前认为它是一种新的优良的抗惊厥药物。
In 1969 Gastaut first reported that clonazepam (Clonazepam, Rivotril, Clo-nopin) treatment of epilepsy and its anticonvulsant effect than diazepam and nitrazepam stability five times stronger, after a wide range of clinical practice found that its efficacy over Stability and stability of nitro stability. It is currently considered a new and excellent anticonvulsant.