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在动物实验和临床研究中业已证实,FDP(Esafosfina,BiomedicaFos Cama Ita)对急性心肌梗塞及休克有肯定的治疗作用。为进一步探讨FDP对急性心肌梗塞再灌注引起的心肌损害有否相同的治疗作用,本文选用了28条麻醉狗,将其左前降支主干(LCA)结扎2小时,然后进行再灌注。治疗组为14条狗,于再灌注前5分钟分别通过静脉输注75mg/kgFDP(10％浓度),然后进以6mg/kg/min的速度维持滴注FDP至总量达500mg/kg。另外14条实验狗为对照组,在相同条件下改以静脉输注相同剂量的葡萄糖生理盐水。再灌后2小时存活的实验狗任其复苏,并于24小时后处死以获取心肌梗塞面积的解剖学依据。
In animal experiments and clinical studies have confirmed that FDP (Esafosfina, BiomedicaFos Cama Ita) acute myocardial infarction and shock have a positive therapeutic effect. In order to further investigate whether FDP has the same therapeutic effect on myocardial damage caused by reperfusion of acute myocardial infarction, 28 anesthetized dogs were used to ligate left anterior descending artery (LCA) for 2 hours and then reperfused. Fourteen dogs in the treatment group were intravenously infused with 75 mg / kg FDP (10% concentration) intravenously 5 minutes before reperfusion, and then instilled FDP to a total of 500 mg / kg at a rate of 6 mg / kg / min. The other 14 experimental dogs as the control group, under the same conditions changed to intravenous infusion of the same dose of glucose saline. Experimental dogs survived 2 hours after reperfusion were allowed to revive and sacrificed 24 hours later to obtain an anatomical basis for infarct size.