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喉色素沉着病非常少见,Goldman(1972)复习以往文献仅有2例报道。氏等在喉癌放射治疗后,注意到粘膜内有广泛的黑素沉着病变,并在以后几个未经选择的尸检中做连续切片发现喉粘膜有黑素细胞。Busuttil(1976)在喉的活检组织鳞状上皮基底层内也发现黑素细胞,并在15个连续切片中发现与Langerhan氏细胞(以前认为是一种退变的黑素细胞,但目前认为有不同的来源)相似的细胞。作者报告了5例老年患者经病理证实的喉黑素沉着病,其病理组织检查均见喉粘膜基底层中有黑素沉着的上皮细胞和黑素细胞(有1例未见明确的黑素细胞);1例作了三次活检,前两次均见于喉粘膜基底层有黑素细胞并于粘膜间质中有慢性炎症细胞浸润,第三次活
Laryngeal pigmentation is very rare, and Goldman (1972) reviewed only two cases in previous literature. After radiotherapy of laryngeal cancer, Shi et al. noted extensive melanin pigmentation in the mucosa and continued serial sections in several unselected autopsies to find melanocytes on the laryngeal mucosa. Busuttil (1976) also found melanocytes in the squamous epithelial basal layer of the biopsy of the larynx, and was found in 15 consecutive sections with Langerhan’s cells (previously considered to be a degenerative melanocyte, but currently considered to have Different sources) similar cells. The authors reported pathologically confirmed leptostomosis in 5 elderly patients. Histopathological examinations showed melanotic pigment epithelial cells and melanocytes in the basal layer of the laryngeal mucous membrane. There was no clear melanocyte in 1 patient. ); 1 case made three biopsy, the first two were found in the basal layer of the laryngeal melanocytes and chronic inflammatory cell infiltration in the mucosal stroma, the third time