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目的观察亚标准剂量静脉丙种球蛋白(Sub-HD-IVIG)采用两种用法治疗急性特发性血小板减少性紫癜(AITP)临床疗效。方法62例AITP患者采取历史对照分组,采用Sub-HD-IVIG的两种用法(0.2g/(kg.d)×5d和1.0g/(kg.d)×1d)治疗,观察临床出血症状、血小板计数变化。结果两组患者的近期疗效相仿,血小板计数峰值、出血症状控制时间相近,差异无显著性(P>0.05),但血小板计数开始上升、升至≥50×109/L及达峰值的时间有显著性差异(P<0.05)。两组患者的治疗费用及住院天数亦有显著性差异(P<0.05)。结论两种用法均能取得良好效果,1天用法组起效更快,更经济,值得推广。
Objective To observe the clinical efficacy of sub-standard intravenous gamma globulin (AIGP) in the treatment of acute idiopathic thrombocytopenic purpura (AITP) by two methods. Methods Sixty-two patients with AITP were divided into two groups: control group (0.2g / (kg · d) × 5d and 1.0g / (kg · d) × 1d). The clinical symptoms, Change in platelet count. Results The two groups of patients had similar curative effect in the short term, peak time of platelet count and control of bleeding were similar (P> 0.05), but platelet count began to rise and reached the peak of ≥50 × 109 / L Sex differences (P <0.05). There was also a significant difference between the two groups in the cost of treatment and days of hospitalization (P <0.05). Conclusion Both of these methods can achieve good results. The one-day treatment group is faster, more economical and worth promoting.