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目的 探讨术前给予选择性环氧化酶2抑制剂塞来昔布超前镇痛效果.方法 60例全麻下开胸行肺部手术患者均分为三组.术后均采用相同配方芬太尼0.5 mg行病人自控静脉镇痛(PCIA).A组术前3 d～术后7 d 口服塞来昔布200 mg,一日2次;B组仅于术后121服塞来昔布7 d;C组仅行PCIA.记录术后8、24和36 h VAS疼痛评分.结果 A组术后三个观察时点的痛觉VAS评分明显低于C组,24、36 h的疼痛视觉模拟评分(VAS)评分明显低于B组,PCIA自主给药次数少.结论 术前使用塞来昔布的镇痛效果优于单纯术后用药.“,”Objective To investigate the preemptive analgesia effect of celebrex (cyclooxygenase-2 inhibitor) in patients undergoing lobectomy. Methods Sixty patients scheduled for thoracotomy under general anesthesia were divided into three groups with 20 cases each, who were given patient-controlled intravenous analgesia with fentanyl 0. 5 mg. The patients in group A received additional oral celebrex 200 mg bid for 10 days ( 3 days before and 7 days after surgery), those in group B received the same dose of celebrex for 7 days after surgery. Group C was not given celebrex as the control. Visual analog scores (VAS) were assessed at 6, 20, and 36 h postoperatively. Results VAS scores at 24 and 36 h were lower in group A than those in group B (P<0. 05), which at 8, 24 and 36 h were lower in group A than those in group C (P<0. 05). PCA times were less in group A than those in groups of B and C (P<0. 05), which were less in group B than those in group C (P<0. 05). Conclusion Preoperative analgesia with celebrex is better than postoperative administration of it.