目的观察并探讨低分子肝素钙联合复方丹参滴丸治疗不稳定型心绞痛临床治疗效果及安全性。方法选取我院2007年5月至2010年6月收治不稳定型心绞痛患者193例,随机分为两组,其中对照组98例,采用硝酸酯类药物,他汀类药物,钙拮抗剂及阿司匹林等常规药物治疗;实验组95例,在对照组治疗基础上,采用复方丹参滴丸口服(10粒/次,3次/d)及低分子肝素钙皮下注射(4000U/次,2次/d)联合疗法;疗程均为4周,疗程结束后评价临床治疗效果及安全性。结果临床治疗效果分析,对照组患者中治疗总有效率为69.4%;实验组患者治疗总有效率为93.7%。实验组患者治疗总有效率明显高于对照组,组间比较差异有统计学意义(P<0.05);心电图改善效果分析,对照组患者治疗总有效率为71.4%;实验组患者治疗总有效率为93.7%;实验组患者心电图改善总有效率明显高于对照组,组间比较差异有统计学意义(P<0.05);两组患者治疗前后PT、APTT指标值比较无统计学差异(P>0.05),同时组间比较差异亦无统计学意义(P>0.05);同时两组患者治疗过程中均无凝血功能障碍及猝死等严重并发症发生。结论低分子肝素钙联合复方丹参滴丸治疗不稳定型心绞痛临床效果确切,治疗有效率高,且对凝血功能无严重影响,不良反应较少,具有临床推广使用价值。 Objective To observe and explore the clinical effect and safety of low molecular weight heparin combined with compound Danshen dripping pills in the treatment of unstable angina pectoris. Methods A total of 193 patients with unstable angina pectoris who were admitted to our hospital from May 2007 to June 2010 were randomly divided into two groups, of which 98 patients in the control group were treated with nitrates, statins, calcium antagonists and aspirin The rats in the experimental group were treated with Fufang Danshen Diwan orally (10 capsules / time, 3 times / d) and low molecular weight heparin calcium subcutaneously (4000U / time, twice daily) on the basis of the control group. Combination therapy; treatment are 4 weeks after the end of treatment evaluation of clinical efficacy and safety. Results Analysis of clinical treatment results showed that the total effective rate in the control group was 69.4%. The total effective rate in the experimental group was 93.7%. The total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.05); analysis of ECG improvement effect, the control group, the total effective rate of treatment was 71.4%; experimental group, the total effective rate of treatment (93.7%). The total effective rate of ECG and ECG in experimental group was significantly higher than that in control group (P <0.05). There was no significant difference in PT and APTT before and after treatment between two groups (P> 0.05), meanwhile there was no significant difference between the two groups (P> 0.05). At the same time, no serious complications such as coagulation dysfunction and sudden death occurred during the course of treatment. Conclusion Low molecular weight heparin combined with compound Danshen dripping pills for the treatment of unstable angina pectoris has definite clinical effect, high effective rate of treatment, no serious effect on coagulation function and few adverse reactions, and has the value of clinical popularization and use.