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目的研究Livin和COX-2在宫颈癌组织中的表达及二者的关系。方法应用免疫组化SP法检测Livin和COX-2蛋白在68例宫颈癌组织中的表达情况。结果 Livin和COX-2蛋白在正常宫颈组织均无表达,而在宫颈癌组织中的阳性表达率显著增高(P<0.01);淋巴结转移组Livin和COX-2蛋白表达的阳性率均高于无淋巴结转移组(P<0.05);且在宫颈癌组织中Livin和COX-2蛋白表达呈正相关。结论 Livin和COX-2的高表达可能在宫颈癌的发生及淋巴结转移中起重要作用,两者在宫颈癌发生中可能具有协同作用。联合检测宫颈癌中Livin和COX-2蛋白表达对进一步了解宫颈癌的恶性程度及判断预后有一定的应用价值。
Objective To study the expression of Livin and COX-2 in cervical cancer and their relationship. Methods Immunohistochemical SP method was used to detect the expression of Livin and COX-2 in 68 cases of cervical cancer. Results The positive expression rates of Livin and COX-2 protein in cervical cancer tissues were significantly higher than those in normal cervical tissues (P <0.01). The positive rates of Livin and COX-2 protein in lymph node metastasis were significantly higher than those without Lymph node metastasis group (P <0.05), and the expression of Livin and COX-2 protein in cervical cancer tissues was positively correlated. Conclusion The high expression of Livin and COX-2 may play an important role in the occurrence of cervical cancer and lymph node metastasis. Both of them may play a synergistic role in the development of cervical cancer. Joint detection of cervical cancer Livin and COX-2 protein expression of cervical cancer to further understand the degree of malignancy and prognosis of a certain value.