慢性粒细胞性白血病急性变(下简称慢粒急变)为慢粒终末阶段的主要表现。一般认为:急变发生率在58％～80％之间;确诊慢粒至急变的时间为3～64个月;急变后的病程为3个月至1年;80％慢粒病人死于急变。Ph′染色体(系慢粒患者体内特有的标记染色体。其特点是异常短小,系第22对染色体的长臂缺失与第9号的长臂易位所致。由于此染色体于1960年在美国费城首次发现,故称为Ph′染色体)阴性的慢粒患者对治疗反应差,更易发生急变。到目前为止慢粒还无理想的治疗方 Acute changes in chronic myelogenous leukemia (hereinafter referred to as CML) is the main manifestation of CML stage. Generally believed that: the incidence of catastrophic 58% to 80%; diagnosed Cough to catharsis time is 3 to 64 months; catastrophic course of disease is 3 months to 1 year; 80% of patients died of blast crisis. Ph ’chromosome (Department of chronic granulocytes in patients with specific markers chromosome is characterized by a very short, Department of chromosome 22 long arm deletion and No. 9 long arm translocation due to this chromosome in 1960 in the United States Philadelphia For the first time found, so called Ph ’chromosome) negative patients with chronic slow response to treatment, more prone to rapid change. Cough so far there is no ideal treatment