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钙拮抗剂通过减少胃肠平滑肌收缩和阻止细胞分泌,有调节胃肠道功能的作用。动物实验表明,异搏定(verapamil)和硫氮(艹卓)酮(diltiazem)可减少食管平滑肌收缩,降低蠕动幅度和低位食管括约肌压力。
Calcium antagonists have the effect of regulating the function of the gastrointestinal tract by reducing the contraction of the gastrointestinal smooth muscle and preventing the secretion of cells. Animal experiments show that verapamil and diltiazem reduce esophageal smooth muscle contraction, reduce the amplitude of peristalsis and lower esophageal sphincter pressure.