包括胰岛母细胞增生症在内的胰岛细胞增生常由于产生过多的胰岛素而导致低血糖。然而在所谓先天性异常的Donohu’s病中胰岛细胞增生也可继发于对胰岛素的耐受。本文报导一例自家抗体阻断胰岛素受体引起的高血糖的胰岛β细胞增生。 女性,40岁,死前患糖尿病19个月。无糖尿病家族史。每天用2,000单位的高剂量胰岛素治疗,仍有糖尿存在。双手、颈部、背部、腋窝及股部皮肤增厚,有棘皮症的色素斑,表浅软组织钙化,肺功 Islet cell proliferation, including islet cell hyperplasia, often leads to hypoglycemia due to excess insulin production. However, in so-called Donohu’s disease with so-called congenital abnormalities, islet cell proliferation can also be secondary to insulin resistance. This article reports a case of autoantibodies blocking hyperinsulinemia of pancreatic β-cell hyperplasia caused by insulin receptors. Female, 40 years old, diabetes mellitus before death 19 months. Family history without diabetes. With 2,000 units per day of high-dose insulin treatment, there is still diabetes. Hands, neck, back, axillary and thigh thickening of the skin, with acanthosis pigment spots, superficial soft tissue calcification, lung function