Tocainide是一种利多卡因的伯胺类衍生物,口服应用时对抑制室性过早搏动有效。迄今,所有资料均为短程治疗。本文报告室性心律失常tocainide长程治疗的初步经验,探讨其疗效、副作用以及长程治疗中tocainide血浆浓度的稳定性。方法:17例室性心律失常患者,年龄为25～68岁。临床诊断为冠状动脉疾患8例、二尖瓣脱垂症3例、正常心脏3例、因主动脉瓣狭窄而作主动脉瓣换置术2例、重度心肌病1例。9例有反复持久的室性心动过速或心室颤动既往史、3例有非持久然而症状严 Tocainide, a primary amine derivative of lidocaine, is effective for the inhibition of ventricular premature beats when administered orally. To date, all data are brachytherapy. This article reports the initial experience of long-term treatment of ventricular arrhythmias with tocainide to investigate its efficacy, side effects and the stability of tocainide plasma concentrations in long-term treatment. Methods: Seventeen patients with ventricular arrhythmia, aged from 25 to 68 years. Clinical diagnosis of coronary artery disease in 8 cases, mitral valve prolapse in 3 cases, 3 cases of normal heart due to aortic valve stenosis for aortic valve replacement in 2 cases, 1 case of severe cardiomyopathy. Nine patients had long-lasting sustained ventricular tachycardia or ventricular fibrillation in the past, three cases of non-persistent, but the symptoms are severe