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目的:分析多西他赛(TXT)+顺铂(DDP)方案联合放疗治疗局部晚期鼻咽癌的疗效和预后情况。方法:选择2003年1月-2006年12月收治的初治局部晚期鼻咽癌患者59例,观察TXT+DDP联合放疗治疗局部晚期鼻咽癌的疗效、预后及其影响因素,计算生存率及局部控制率。结果:59例患者,5年生存率、无复发生存率、无转移生存率分别为72%、82%和54%。与总生存率有关的因素有T分期、N分期、92福州分期、年龄、治疗前贫血、KPS评分,与无复发生存率有关的因素有T分期、贫血、KPS评分。结论:TXT+DDP诱导化疗及同期放/化疗加辅助化疗治疗局部晚期鼻咽癌,远期生存率好,5年无复发生存率及5年无远转生存率有较大的提高且毒副反应轻。早期发现患者,治疗前改善一般状况及纠正贫血有助提高生存率。
Objective: To analyze the efficacy and prognosis of docetaxel (TXT) + cisplatin (DDP) combined with radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods: 59 patients with newly diagnosed locally advanced nasopharyngeal carcinoma admitted from January 2003 to December 2006 were selected. The curative effect, prognosis and influencing factors of TXT + DDP combined with radiotherapy in the treatment of locally advanced nasopharyngeal carcinoma were observed. The survival rate and Local control rate. Results: Fifty-nine patients had 5-year survival, no recurrence, and no-metastasis survival rates of 72%, 82% and 54%, respectively. Factors related to overall survival were T stage, N stage, 92 Fuzhou stage, age, pre-treatment anemia, KPS score, and non-recurrence-related factors were T stage, anemia and KPS. Conclusions: TXT + DDP-induced chemotherapy and concurrent radiotherapy / chemotherapy combined with adjuvant chemotherapy in the treatment of locally advanced nasopharyngeal carcinoma have a good long-term survival rate, 5-year relapse-free survival rate and 5-year long-term survival rate, Light reaction. Early detection of patients, to improve the general condition before treatment and to correct anemia can help improve the survival rate.