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测定了41例NIDDM病人(25例有大血管病变,16例无血管并发症)及33例正常人的血浆Lpo、ApoA_1、ApoB和脂蛋白。NIDDM各组与正常对照组、NIDDM合并大血管病变组与无血管病变组之间比较,前者Lpo、ApoB水平升高,ApoA_1水平下降,且差异极显著。提示上述变化与NIDDM大血管病变的发生关系密切。NIDDM病人血浆Lpo水平与ApoB、LDL-C、TC、TG的水平呈极显著正相关,提示NIDDM病人Lpo代谢异常与其他血脂代谢异常有伴同关系。
Plasma Lpo, ApoA_1, ApoB and lipoprotein were measured in 41 patients with NIDDM (25 with macrovascular disease and 16 with no vascular complications) and 33 normal controls. NIDDM groups and normal control group, NIDDM with macrovascular disease group and no vascular disease group comparison, the former Lpo, ApoB levels, ApoA_1 levels decreased, and the difference was significant. Tip of the above changes and the occurrence of NIDDM macrovascular disease are closely related. The level of ApoB, LDL-C, TC and TG in plasma Lpo of NIDDM patients was significantly and positively correlated, suggesting that abnormal Lpo metabolism in patients with NIDDM may be associated with other dyslipidemia.