慢心律原为抗惊厥药,结构与利多卡因和室安卡因相类似,在动物模型中发现它有抑制室性心律失常的作用,在欧洲大陆和英国,1976年起已应用于临床,在北美则尚在研究中。电生理和药理学本药的化学结构、神经和心肌细胞电生理效应、实验和临床抗心律失常作用都类似利多卡因,但不能简单认为它是后者的口服代用品。本药在狗中的血浆浓度达3毫克/升时,能使60％狗冠状动脉结扎引起的室性心动过速消除,当血浆浓度达5.3毫克/升时,则 Slow heart rhythm was originally an anticonvulsant drug with a structure similar to that of lidocaine and ventricular card anemia and found to have the effect of inhibiting ventricular arrhythmias in animal models and has been used clinically since 1976 in Europe and the United Kingdom North America is still under study. Electrophysiology and pharmacology The chemical structure of the drug, the electrophysiological effects of nerve and cardiomyocytes, and experimental and clinical anti-arrhythmic effects are similar to lidocaine, but can not be simply considered an oral substitute for the latter. The drug in dogs when the plasma concentration of 3 mg / L, can make 60% of the dog coronary artery ligation caused by the elimination of ventricular tachycardia, when the plasma concentration of 5.3 mg / L, then