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目的：研究新合成的血小板激活因子受体拮抗剂反式－２，６－双（３，４二甲氧苯基）－四氢吡喃（ＳＺ－１）对沙土鼠脑缺血的保护作用。方法：结扎沙土鼠两侧颈总动脉造成短暂性脑缺血，缺血时间为１０ｍｉｎ，再灌注时间为５ｄ。处死后计数沙土鼠海马ＣＡ１区７５０μｍ长度内神经无数。在缺血前３０ｍｉｎ腹腔给ＳＺ－１（１０ｍｇ／ｋｇ），比较假手术组、缺血组及给药组存活的神经元数。结果：缺血组神经元的存活数较假手术组非常显著的减少（从１５３．５±１．６下降到３７．４±１１．７，Ｐ＜０．０１），１０ｍｇ／ｋｇＳＺ－１可使神经元存活数显著增加（从３７．４±１１．７上升到１３４．８±７．４，Ｐ＜０．０１）。结论：ＳＺ－１对沙土鼠脑缺血引起的神经损伤具有良好的神经保护作用。
AIM: To investigate the protective effect of trans-2,6-bis (3,4-dimethoxyphenyl) -tetrahydropyran (SZ-1), a newly synthesized platelet activating factor receptor antagonist, on cerebral ischemia in gerbils . Methods: Twenty-two hours after cerebral ischemia, the ischemic time was 10 minutes and the reperfusion time was 5 days. After sacrifice count gerbils in the hippocampal CA1 area 750μm nerve length numerous. SZ-1 (10 mg / kg) was intraperitoneally administered 30 min before ischemia, and the number of neurons surviving in the sham operation group, the ischemia group and the administration group was compared. Results: The number of neurons in ischemic group decreased significantly (from 153.5 ± 1.6 to 37.4 ± 11.7, P <0.01) The neuronal survival number increased significantly (from 37.4 ± 11.7 to 134.8 ± 7.4, P <0.01). Conclusion: SZ-1 has a good neuroprotective effect on neurological injury induced by cerebral ischemia in gerbils.