培氟沙星(甲氟哌酸、培福新peflacine)系氟喹诺酮类药物,抗菌谱广泛,在难治性和重症感染的治疗中显示了很好的抗菌活性。它不仅对G~-需氧菌有良好的抗菌活性,对某些G~-菌(葡萄球菌)亦有效。①适应证:适用于复杂性泌尿道感染,腹腔内感染,伤寒,骨感染,下呼吸道感染,败血症,盆腔感染,软组织,耳鼻喉及免疫功能低下等感染性疾病。②本药和其他抗菌药之间几乎没有交叉耐药性。据报道,培氟沙星的疗效已在755次经证实的感染中得到评估,临床治愈率和改善率>90%,细菌消除率85%～90％。③口服或静脉注射对疗效无影响,因为二者 Pefloxacin (norfloxacin, pefloxacin peflacine) Department of fluoroquinolones, antimicrobial spectrum is broad, in the treatment of refractory and severe infections showed good antibacterial activity. It not only has good antibacterial activity against G ~ - aerobic bacteria, but also is effective against some G ~ (Staphylococcus) bacteria. ① indications: for complex urinary tract infections, intra-abdominal infections, typhoid, bone infections, lower respiratory tract infections, sepsis, pelvic infections, soft tissue, ENT and immune dysfunction and other infectious diseases. ② almost no cross-resistance between the drug and other antibacterial drugs. It has been reported that the efficacy of pefloxacin has been evaluated in 755 confirmed infections with clinical cure rates and improvement rates> 90% and bacterial elimination rates of 85% to 90%. ③ oral or intravenous injection has no effect on the efficacy, because both