论文部分内容阅读
目的观察卧床模拟失重所致血浆肾素活性（ＰＲＡ）、醛固酮（Ａｌｄ）及前列腺素（ＰＧＩ２）的变化和ＬＢＮＰ对抗措施对上述激素的影响。方法１２名健康男性志愿者进行了２１ｄＨＤＴ－６°卧床实验。被试者年龄２３．７±５．０岁，随机等分为对照组（ＣＯＮ）和下体负压（ＬＢＮＰ）组。ＬＢＮＰ组在卧床最后一周进行下体负压锻炼（－３０ｍｍＨｇ，１ｈ／ｄ）。卧床前、卧床第２、４、１１天及卧床结束日清晨分别抽取肘静脉血。结果与卧床前相比，Ａｌｄ在第２天显著下降（ＣＯＮ－３０％，Ｐ＜０．０５；ＬＢＮＰ－３８％，Ｐ＜０．０１），在第１１天显著上升（ＣＯＮ＋３０％，Ｐ＜０．０５；ＬＢＮＰ＋４８％，Ｐ＜０．０１）。ＰＲＡ在第４天达到峰值（Ｐ＜０．０５），第２２天回落到低于对照水平。ＰＧＩ２在ＨＤＴ过程中均高于对照水平。对照组在第２２天增加＋２６０％（Ｐ＜０．０１），ＬＢＮＰ组在第１１天，第２２天分别升高１４９％，１０２％（Ｐ＜０．０５）。采用ＬＢＮＰ对抗措施后，ＰＲＡ，Ａｌｄ在两组间无明显差别，ＰＧＩ２在ＬＢＮＰ组未进一步升高。结论２１ｄ头低位卧床导致ＰＲＡ、Ａｌｄ的一过性升高及ＰＧＩ２持续性升高。
Objective To observe the changes of plasma renin activity (PRA), aldosterone (Ald) and prostaglandin (PGI2) induced by simulated bed weight and the effects of LBNP countermeasures on these hormones. Methods Twelve healthy male volunteers underwent 21d HDT-6 ° bed rest. Subjects aged 23.7 ± 5.0 years, were randomly divided into control group (CON) and lower body negative pressure (LBNP) group. LBNP group in the last week of bedridden lower body exercise (-30mmHg, 1h / d). Bed rest, bed 2,4 and 11 days and bed rest early in the morning were drawn elbow venous blood. Results Ald decreased significantly on day 2 (CON-30%, P <0.05; LBNP-38%, P <0.01) and significantly increased on the 11th day (CON + 30%, P < 0.05; LBNP + 48%, P <0.01). PRA peaked on day 4 (P <0.05) and fell back to below control levels on day 22. PGI2 in the HDT process are higher than the control level. The control group increased by + 260% on day 22 (P <0.01), and the LBNP group increased by 149% and 102% on day 11 and 22 respectively (P <0.05). After using LBNP countermeasure, PRA, Ald in the two groups no significant difference, PGI2 in the LBNP group did not further increase. Conclusions The 21 d head-low bed rest resulted in a transient increase of PRA and Ald and a persistent increase of PGI2.