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本文利用2698例人胚绒毛膜研究沈阳、郑州及大连三个地区空气中的污染物在日常低水平、多途径、长时间的暴露情况下,直接对人类子代的影响。结果显示我国大气污染属煤烟型,污染的综合指数以沈阳最高,郑州次之,大连最低。三地区人胚绒毛组织染色体的数目和/或结构畸变率与大气污染的严重程度有关,污染严重则其异常发生率亦高。在大气中,主要有害物质为二氧化硫(SO_2),它对绒毛染色体的多倍体,超二倍体,嵌合体及染色体结构异常的发生率均有影响,且与日均浓度之间存在着剂量一效应的关系。当SO_2超越最高容许浓度时,绒毛染色体的异常发生率分别增加1—3倍。通过本研究不但为国家治理环境污染和提高人口素质提供了科学的依据,而且还证实了此研究方法可作为一个体内遗传突变效应的实验模式值得推广。
In this paper, 2698 human embryonic chorion was used to study the effects of airborne pollutants in the air of Shenyang, Zhengzhou and Dalian on the offspring of human beings at low, multi-path and long-term exposures. The results show that China’s air pollution is a soot-type, the comprehensive index of pollution in Shenyang highest, followed by Zhengzhou, Dalian lowest. The number of chromosomes and / or the rate of structural aberration in human chorionic villi in the three regions are related to the severity of atmospheric pollution, and the incidence of abnormal pollution is also high. In the atmosphere, the main pollutant is sulfur dioxide (SO 2), which affects the incidence of polyploidy, diploidism, chimerism and chromosomal abnormalities in chorionic chromosomes, and there is a dose The effect of a relationship. When SO_2 exceeds the maximum allowable concentration, the abnormal incidence of chorionic chromosomes increased by 1-3 times. The study not only provides a scientific basis for the government to control environmental pollution and improve population quality, but also confirms that this research method can be used as an experimental model of in vivo genetic mutation effect worthy of promotion.