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抗血吸虫病新药毗噻硫酮[化学名:4-甲基-5-(2’-吡嗪基)-1,2-二噻茂-3-硫酮](国外商品名Oltipraz)对感染曼氏血趿虫的小白鼠,ED_(50)为每天日服50 mg/kg,连服5天,活性高于硝唑咪2倍。猴体给药ED_(50)为20mg/kg。小白鼠LD_(50)为>5g/kg(口服)。鼠与猴体内,无诱变因素和免疫抑制作用。另给剂量45mg/鼠,分3天灌胃,减虫率为71％,减雌率88％。临床治疗埃及、曼氏和间插血吸虫病321例,剂量为每天15mg/kg与25mg/kg连服2天,低剂量组治愈率为86％,高剂量组治愈率为94％。若增加剂量、延长疗程,则疗效更佳。
Anti-schistosomiasis new drug Valsulfuron [chemical name: 4-methyl-5- (2’-pyrazinyl) -1,2- dithiol-3-thione] (foreign trade name Oltipraz) Blood clam mice, ED_ (50) daily serving 50 mg / kg, and even served 5 days, activity is higher than nitazoxan 2 times. The monkey administered ED_ (50) was 20 mg / kg. Mouse LD_ (50)> 5g / kg (oral). Rats and monkeys, no mutagenic factors and immunosuppressive effects. The other to the dose of 45mg / mouse, gavage 3 days, worm reduction rate of 71%, reduced female rate of 88%. Clinical treatment of Egypt, Manchurian and inter-seminal schistosomiasis in 321 cases, the daily dose of 15mg / kg and 25mg / kg with 2 days, low-dose group was 86%, high-dose group was 94%. If you increase the dose, extend the course of treatment, the effect is better.