在所有应用慢作用抗风湿药物的患者中,半数以上在2年内因其毒性或无效而停药。虽然最初的研究表明,每天应用5mg/kg 以上的环孢素(cyclosporin)能减轻关节炎症,但有严重肾毒性。本文应用随机安慰剂对照方法,观察小剂量环孢素治疗类风湿性关节炎的效果与安全性。 Of all patients with slow-acting anti-rheumatic drugs, more than half discontinued due to their toxicity or ineffectiveness within 2 years. Although initial studies have shown that daily application of 5 mg / kg cyclosporin can reduce arthritis, but with severe nephrotoxicity. In this paper, a randomized placebo-controlled method to observe the effect and safety of low-dose cyclosporine in the treatment of rheumatoid arthritis.