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目的制作阿霉素诱导大白鼠胎仔出现先天性十二指肠闭锁的模型。方法Ｗｉｓｔａｒ孕鼠１０只，于妊娠第６至第９天腹腔注射阿霉素１７５ｍｐ／ｋｇ，妊娠２０天剖宫取胎仔，做解剖、电镜及光镜观察。结果用药组获胎仔３２只，十二指肠闭锁２６例（８１．３％），其中腔内闭锁１５．４％，闭锁近远端由纤维或胰腺相连者占４６．２％，近远端游离者为３８．５％，十二指肠闭锁畸形均伴有胰腺发育异常，９例胰颈、胰体及胰尾缺如，１７例胰体和胰尾缺如，另外，镜下见部分胰腺腺泡呈发育不良改变。结论阿霉素诱导大鼠胎仔出现先天性十二指肠畸形和胰腺畸形是一种可靠的模型制作方法。
Objective To make a model of adriamycin-induced congenital duodenal atresia in fetal rats. Methods 10 Wistar pregnant rats were injected intraperitoneally with doxorubicin 175mp / kg on the 6th to 9th day of gestation, fetus fetus were taken from the cesarean section on the 20th day of gestation and were dissected, electron microscope and light microscope. Results Twenty-two fetuses and 26 duodenal atresia (81.3%) were found in the treatment group, of which 15.4% were blocked in the cavity and 46.2% in the proximal and distal ends by fiber or pancreas. The proximal and distal ends Free 38.5%, duodenal atresia associated with abnormal pancreatic development, 9 cases of pancreatic neck, pancreatic body and pancreatic tail absence, 17 cases of pancreatic body and pancreatic tail missing, in addition, see the mirror part Pancreatic acinar showed dysplastic changes. Conclusion Adriamycin-induced fetal duodenal deformity and pancreatic deformity is a reliable method of model making.