目的观察醒脑静注射液治疗重型手足口病的效果。方法将60例重症儿童手足口症患儿根据随机数字表法分为试验组和对照组各30例。2组患者均给予甘露醇和甲泼尼龙进行基础治疗。对照组在此基础上给予利巴韦林静脉滴注;试验组在对照组治疗方案基础上加用醒脑静注射液。1个疗程后观察比较2组患者的各临床症状消退情况以及治疗效果。结果试验组总有效率为96.7%高于对照组的80.0%,差异有统计学意义(P<0.05)。2组发热、皮疹情况比较差异无统计学意义(P>0.05)。试验组退热时间、神经系统症状消退时间及平均住院时间均短于对照组,差异均有统计学意义(P<0.05)。治疗过程中,2组患儿未发生严重不良反应。结论醒脑静注射液治疗重症手足口病取得良好临床效果,治疗中未发现不良反应,值得临床广泛推广应用。 Objective To observe the effect of xingnaojing injection in treating severe hand-foot-mouth disease. Methods Sixty children with HFMD were divided into experimental group and control group according to random number table method. Two groups of patients were given mannitol and methylprednisolone for basic treatment. The control group was given ribavirin on the basis of intravenous drip; the experimental group in the control group based on the treatment plan plus xingnaojing injection. After a course of treatment were observed in two groups of patients clinical symptoms and treatment of regression. Results The total effective rate of the experimental group was 96.7% higher than that of the control group (80.0%), the difference was statistically significant (P <0.05). There was no significant difference between the two groups in fever and rash (P> 0.05). The antipyretic time, the regression time of neurological symptoms and the average length of hospital stay in the experimental group were shorter than those in the control group, with significant differences (P <0.05). During treatment, two groups of children did not occur serious adverse reactions. Conclusion Xingnaojing Injection has a good clinical effect in the treatment of severe hand-foot-mouth disease. No adverse reactions were found in the treatment. It is worth widely clinical application.