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目的研究骨髓活组织检查在转移性癌诊断中临床意义。方法观察68例转移性癌患者骨髓病理学改变及特点,分析骨髓活检结果与骨转移癌临床诊断符合情况。结果转移性癌常以贫血和骨痛为首发表现,骨髓切片可见癌细胞散在或成簇分布,条索状或巢状排列,且浸润程度与原发肿瘤无关;而骨髓涂片中基质常有纤维组织增生、骨小梁破坏。切片与涂片对转移癌的诊断阳性率分别为100%和56%,两者比较有明显差异(P<0.01)。结论对于临床不明原因贫血、骨痛的患者,建议进行骨髓活检,骨髓活检对诊断骨髓转移性癌有重要临床价值。
Objective To study the clinical significance of bone marrow biopsy in the diagnosis of metastatic carcinoma. Methods 68 patients with metastatic cancer were observed pathological changes and characteristics of bone marrow, bone marrow biopsy results and clinical analysis of bone metastases consistent with the situation. Results Anemia and bone pain were the first manifestation of metastatic cancer. The bone marrow showed scattered or clustered cancer cells arranged in the shape of cord or nests, and the degree of infiltration was not related to the primary tumor. In the case of bone marrow smear, Fibrous tissue proliferation, trabecular destruction. The positive rates of biopsy and smears on metastatic carcinoma were 100% and 56%, respectively (P <0.01). Conclusion In patients with clinical anemia and bone pain with unknown causes, bone marrow biopsy and bone marrow biopsy are suggested to have important clinical value in the diagnosis of bone marrow metastatic carcinoma.