论文部分内容阅读
1例56岁男性肝移植患者口服他克莫司2.5 mg,1次/12 h和考麦酚吗乙酯500 mg,1次/12 h。他克莫司血浓度为6.8ng/ml。患者因持续低热给予哌拉西林钠-他唑巴坦钠和甲硝唑治疗。入院第8天为预防真菌感染加用氟康唑胶囊(200 mg)1粒,2次/d。他克莫司血浓度为7.9 ng/ml。氟康唑治疗第10天,患者出现反应迟钝、双眼向左侧斜视、上肢抽搐、牙关紧闭及意识不清。他克莫司浓度为12.4 ng/ml,他克莫司剂量调整为1.5 mg,1次/d。患者症状缓解,住院第35天他克莫司血浓度为7.8 ng/ml。
One 56-year-old male liver transplant patient received oral tacrolimus 2.5 mg, once / 12 h and 500 mg of testosterone, once / 12 h. Tacrolimus blood concentration of 6.8ng / ml. Patients were treated with piperacillin sodium-tazobactam sodium and metronidazole due to continued low fever. Admission to hospital on the 8th to prevent fungal infection plus fluconazole capsules (200 mg) 1, 2 times / d. The tacrolimus blood concentration was 7.9 ng / ml. Fluconazole treatment on the 10th day, the patient appeared unresponsive, his eyes strabismus to the left, upper extremity convulsions, trismus and confusion. Tacrolimus concentration of 12.4 ng / ml, tacrolimus dose adjusted to 1.5 mg, 1 / d. The patient’s symptoms were relieved, with a tacrolimus concentration of 7.8 ng / ml on day 35 of hospitalization.