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黔西北地区野八角(Illicium simonsii Maxim.)被当地民间用作食用香料,为确保对人的安全性,我们分别对野八角果实的不同剂型进行了急性毒性试验。结果表明,毒性表现以神经系统症状为主,中毒症状随剂量增加而加重;全粉混悬液对小鼠经口LD_(50):雄7.94g/kgbw,雌9.09g/kgbw,属实际无毒范围,而对大鼠,一日剂量达5.5g/kgbw,尚未发生死亡,属实际无毒范围;全粉水提液对小鼠经口LD_(50):雄、雌均为20g/kgbw;种籽水提液对雌小鼠,一日经口剂量已达30g/kgbw,尚无一例死亡,已属无毒范围。
Illicium simonsii Maxim. In northwestern Guizhou Province was used as food flavoring by local people. To ensure human safety, we conducted acute toxicity tests on different dosage forms of wild star aniseed fruit respectively. The results showed that the toxic manifestations of the main symptoms of the nervous system, symptoms of poisoning increased with increasing dose; whole powder suspension of mice oral LD_ (50): male 7.94g / kgbw, 9.09g / kgbw female, is actually no Poisonous range, while the rat, the daily dose of 5.5g / kgbw, has not yet occurred, is actually non-toxic range; whole powder water extract of mice LD_ (50): male and female were 20g / kgbw ; Seed water extract on female mice, the oral dose has reached 30g / kgbw, no case of death, is a non-toxic range.