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目的 应用经塑料包埋骨髓活组织切片技术研究骨髓网硬蛋白纤维与白血病细胞的消长关系。方法 采用Gom ori染色和Masson 三色染色检测16 例急性白血病患者治疗前后骨髓网硬蛋白纤维含量变化。结果 16 例急性白血病患者治疗前后骨髓网硬蛋白纤维阳性例数有明显差异(P< 0.05)。治疗后骨髓网硬蛋白纤维含量呈正常11 例,其中完全缓解(CR)8 例,部分缓解(PR)3 例;而治疗后骨髓网硬蛋白纤维呈异常5 例,其中PR 1 例,未完全缓解(NR) 4例,两者有明显差异(P< 0.05)。另外,8 例CR患者中2 例短期内疾病复发,骨髓网硬蛋白纤维含量又升高呈异常,其中1例第二次CR时,又一次降至正常。结论 骨髓网硬蛋白纤维含量的动态变化,可作为急性白血病患者判定疗效与预测早期复发的一个重要参考指标
Objective To study the relationship between bone marrow fibrosis and leukemia cells by plastic-embedded bone marrow biopsy. Methods Gom ori staining and Masson trichrome staining were used to detect the changes of bone marrow fibrosis protein content in 16 patients with acute leukemia before and after treatment. Results 16 cases of acute leukemia patients before and after treatment of bone marrow fibrosis protein positive cases there was a significant difference (P <0.05). After treatment, the content of bone marrow fibrin fibers was normal in 11 cases, including 8 cases of complete remission (CR) and 3 cases of partial remission (PR). However, there were 5 cases of abnormal fibrinogen in bone marrow after treatment, of which 1 case was PR There were 4 cases of relief (NR), with significant difference (P <0.05). In addition, two of eight patients with CR relapsed within a short period of time, and the content of bone marrow fibrinogen fibers was abnormally elevated. One of the eight CR patients returned to normal again at the second CR. Conclusions The dynamic changes of bone marrow fibrinogen content can be used as an important reference index for determining the efficacy and predicting the early recurrence of acute leukemia