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目的 探讨吡喹酮治疗对日本血吸虫病患者血清抗幽门螺杆菌 H p Ig G水平的影响。方法 利用 H p全菌抗原对流行区 94例日本血吸虫病人治疗前后血清抗 H p Ig G进行检测。结果 治疗后 3、6个月 ,H p感染阳性率分别为 73.4%和70 .2 % (治疗前为 75 .5 % ) ,H p Ig G抗体水平分别为 0 .71± 0 .30和 0 .6 5± 0 .2 1(治疗前为 0 .80± 0 .2 3) ,对照组均有轻度升高。各年龄组 H p感染阳性率和血清 H p Ig G水平均随治疗进展而降低 ,其中 0～ 2 0岁年龄组血清 H p Ig G下降最快。血清抗H p Ig G和同期对应的日本血吸虫 31/ 32 k Da(Sj31/ 32 ) Ig G抗体平均水平及阴转值之间高度相关 (治疗后 3个月 r分别为 0 .85和 0 .6 5 ,治疗后 6个月 r分别为 0 .85和 0 .5 0 )。结论 日本血吸虫病人经吡喹酮治疗后 H p感染阳性率及血清 H p Ig G水平降低 ,日本血吸虫与 H p感染高度相关 ,血吸虫可能作为 H p感染的危险因素之一。
Objective To investigate the effect of praziquantel on serum anti-Helicobacter pylori H p Ig G in patients with schistosomiasis japonica. Methods Serum anti-H p Ig G levels of 94 schistosoma japonicum patients before and after treatment were detected by H p whole bacterial antigen. Results The positive rates of H p infection were 73.4% and 70.2% (75.5% before treatment) respectively at 3 and 6 months after treatment, and the antibody levels of H p Ig G were 0.71 ± 0.30 and 0 .6 5 ± 0.21 (before treatment 0.80 ± 0.23), the control group were mildly elevated. The positive rate of Hp infection and the level of serum H p Ig G in all age groups decreased with the progress of treatment, in which serum H p Ig G decreased most rapidly in 0 ~ 20 years old group. There was a high correlation between serum anti-H p Ig G and the corresponding 31/32 kDa (Sj31 / 32) Ig G antibodies and corresponding negative conversion values (0.85 and 0. 3 months after treatment). 6 5, 6 months after treatment r were 0.85 and 0 .5 0). Conclusions The positive rate of Hp infection and the level of H p Ig G in schistosomiasis japonica patients after praziquantel treatment are decreased. Schistosoma japonicum is highly correlated with H p infection, and schistosomiasis may be one of the risk factors for H p infection.