There are no special recommendations for basic vaccinations in patients with c hronic neurological deficits distinct from the nationwide advocated schedule in Switzerland. Reports describing adverse neurological events possibly related to vaccinations have attracted public attention. It is unclear if patients with chr onic neurological deficits are more reluctantly vaccinated compared to healthy c hildren. We therefore investigated the acceptance of vaccinations in such patien ts and healthy controls in a retrospective case-control study. At the Universit y Children’s Hospital, Basel, Switzerland we investigated 100 patients with chr onic neurological deficits and 200 age-matched healthy controls regarding the i ssue of vaccination rates and ages. The total number of administered vaccination s against diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b ( Hib), mumps, measles, rubella and hepatitis B were significantly lower in patien ts compared to healthy controls ( P< 0.01 for each of the respective vaccines). Patients had an increased risk to receive the third pertussis, diphtheria, and t etanus vaccinations (relative risks (RR) for late vaccination 1.53, 1.53, and 1. 54 respectively, P < 0.01 for all comparisons), the second (RR=1.60, P < 0.05) a nd third Hib vaccinations (RR=1.52, P < 0.05), and the third polio vac cination (RR=1.43, P < 0.05) later than controls. Conclusion:Children with chr onic neurological deficits received fewer vaccinations than healthy controls. In addition, patients received vaccinations later than healthy children. Hence, it may be assumed that children with chronic neurological deficits are at an incre ased risk to acquire preventable infections. Therefore, vaccination should be pr omoted as part of the consultation during a routine appointment with the special ist. There are no special recommendations for basic vaccinations in patients with c hronic neurological deficits distinct from the nationwide advocated schedule in Switzerland. It is unclear if patients with chr onic neurological deficits are more We therefore been in the acceptance of vaccinations in such patien ts and healthy controls in a retrospective case-control study. At the Universit y Children’s Hospital, Basel, Switzerland we investigated 100 patients with chr onic neurological deficits and 200 age-matched healthy controls regarding the i ssue of vaccination rates and ages. The total number of administered vaccinations s against diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b (Hib), mumps, measles, rubella and hepatitis B were significantly lower in patien ts compared to healthy controls (P <0.01 for each of the respective vaccines). Patients had an increased risk to receive the third pertussis, diphtheria, and t etanus vaccinations (relative risks (RR) for late vaccination 1.53, 1.53, and 1. 54 respectively, P <0.01 for all comparisons a nd third Hib vaccinations (RR = 1.52, P <0.05), and the third polio vac cination (RR = 1.43, P <0.05) later than controls. : Children with chr onic neurological deficits received fewer vaccinations than healthy controls. In addition, patients received vaccinations later than healthy children. Therefore, it may be assumed that children with chronic neurological deficits are at an incre ased risk to acquire preventable infections. Therefore, vaccination should be promoted as part of the consultation during a routine appointment with the special ist.