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实验中观察了卡铂(50mg/kg)对灰鼠耳蜗螺旋神经节细胞的急性损害.注药后6小时即可发现在Ⅰ型神经元胞体和神经纤维中有空泡形成.注药后1天可见Ⅰ型神经元内充满大空泡并开始发生坏死.其结果表明卡铂产生对螺旋神经节的毒害相当迅速.提示耳蜗传入神经系统可能是卡铂的第一个靶组织.
Acute injury of spiral ganglion cells of the rat squirrel was observed with carboplatin (50 mg / kg) at 6 hours after injection, and vacuolization was found in the type I neuronal soma and nerve fibers.After injection 1 Type I neurons were filled with large vacuoles and necrosis began to occur.The results showed that the toxicity of carboplatin to spiral ganglion was quite rapid, suggesting that the cochlear afferent nervous system may be the first target tissue of carboplatin.