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目的 新生儿因处于暂时性的免疫功能低下的状态而容易发生感染性疾病 ,也是新生儿发病和死亡的重要原因。寻找指标以早期诊断新生儿感染性疾病是临床和研究的重点之一。本研究探讨血清IL 8、IL 10、IL 13水平在新生儿细菌感染的早期诊断和疗效判断中的意义。方法 用ELISA测定 3组血清各细胞因子的水平。感染组 :2 1例细菌感染的足月新生儿。非感染组 :2 0例非感染性疾病的足月新生儿。脐血组 :30例正常足月新生儿。结果 感染组IL 8、IL 10和IL 13水平 (87.0± 82 .6 ,35 .1± 34.8,2 3.2± 4 6 .2pg/ml)较非感染组升高(5 6 .6± 13.2 ,2 1.6± 12 .9,12 .0± 32 .3pg/ml) (P <0 .0 5 ) ;感染组治疗后IL 8和IL 10水平 (5 1.2± 3.1,18.5±3.3pg/ml)较治疗前下降 (P <0 .0 5 ) ;非感染组IL 13较脐血组 (1.2± 0 .3pg/ml)显著升高 (P <0 .0 5 ) ,IL 8、IL 10在两组间无区别。结论 新生儿细菌感染时血清IL 8、IL 10和IL 13显著升高 ,可做为新生儿细菌感染的参考标志物 ,而IL 8和IL 10的变化有助于评估新生儿感染的治疗效果。
The purpose of neonatal transient immunocompromised prone to infectious diseases, but also an important cause of neonatal morbidity and mortality. Looking for indicators to diagnose neonatal infectious diseases early is one of the focuses of clinical and research. This study was to explore the significance of serum IL-8, IL-10 and IL-13 levels in the early diagnosis and treatment of neonatal bacterial infection. Methods Serum levels of each cytokine were measured by ELISA. Infected group: 21 full-term newborns with bacterial infection. Non-infected group: 20 full-term newborns with noninfectious disease. Cord blood group: 30 normal term newborns. Results The levels of IL-8, IL-10 and IL-13 in the infected group were significantly higher than those in the non-infected group (87.0 ± 82.6, 35.1 ± 34.8,2.22 ± 46.2pg / ml) 1.6 ± 12 .9,12 .0 ± 32.3pg / ml) (P <0.05). The levels of IL-8 and IL-10 in the infected group were significantly lower than those in the untreated group (5 1.2 ± 3.1, 18.5 ± 3.3pg / ml) (P <0.05). IL-13 in non-infected group was significantly higher than that in umbilical cord blood (1.2 ± 0.3pg / ml) (P <0.05) No difference. Conclusions The levels of IL-8, IL-10 and IL-13 in neonates with bacterial infection are significantly increased, which can be used as a reference marker for neonatal bacterial infection. The changes of IL-8 and IL-10 are helpful to evaluate the therapeutic effect of neonatal infection.