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临床上阿托品药物的使用会影响心血管系统的功能,提出通过心率变异信号的复杂度特征值来表征这种影响,并通过特征值的变化来探究药物的影响过程。10个健康自愿者参加了药物实验,在阿托品注射前后,共采集了每个自愿者6组心电信号,数据总长度为180分钟,从心电信号中提取所有数据的心率变异信号,并计算其非线性复杂度特征指标。根据数据结果,建立了阿托品对心血管系统作用过程的数学模型。通过数值仿真对比表明,该模型在临床上可以用作阿托品对心血管系统作用过程的数学描述。
Clinically, the use of atropine drugs can affect the function of the cardiovascular system. It is proposed to characterize this effect through the complexity of eigenvalues of heart rate variability signals and to explore the influence of drugs through the change of eigenvalues. Ten healthy volunteers participated in the drug experiment. Before and after the injection of atropine, a total of six ECG signals were collected for each volunteer. The total length of the data was 180 minutes. The heart rate variability signals of all the data were extracted from the ECG signals and calculated Its nonlinear complexity characteristics index. Based on the data, a mathematical model of the effects of atropine on the cardiovascular system was established. The numerical simulation shows that the model can be used clinically as a mathematical description of the effects of atropine on the cardiovascular system.