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目的：探讨氧自由基在高原出血性休克发生的作用及大量维生素Ｃ的抗休克作用。方法：１６只山羊减压至模拟４０００ｍ高原２４ｈ，然后放血引起休克，将动物分为对照组和维生素Ｃ治疗组。结果：（１）失血期注入少量生理盐水后休克进一步加重；相反，注入维生素Ｃ后，心指数、左室收缩压、ｄｐ／ｄｔｍａｘ、氧运送量、氧耗量和ｐＨ明显增加，而脂质过氧化物（ＬＰＯ）明显降低。（２）输血输液后，对照组仅短暂改善心血管功能，其后血压下降，动物存活时间仅７ｈ３８ｍｉｎ。而维生素Ｃ治疗组，较好保持心血管功能、ＬＰＯ含量正常，活存时间为２０ｈ９ｍｉｎ。结论：氧自由基可能在高原出血性休克发生中起着重要作用，维生素Ｃ有明显抗休克作用
Objective: To investigate the role of oxygen free radicals in plateau hemorrhagic shock and the anti-shock effect of a large number of vitamin C. Methods: 16 goats were depressurized to simulate the 4000m plateau for 24 hours, then the animals were divided into control group and vitamin C treatment group. Results: (1) Shock was further aggravated by injection of a small amount of saline during the period of blood loss; on the contrary, cardiac index, left ventricular systolic pressure, dp / dtmax, oxygen delivery, oxygen consumption and pH were significantly increased after vitamin C injection, Peroxide (LPO) was significantly reduced. (2) After transfusion, the control group only short-lived to improve the cardiovascular function, then the blood pressure dropped, the animal survival time was only 7h38min. The vitamin C treatment group, better maintain cardiovascular function, normal LPO content, survival time of 20h9min. Conclusion: Oxygen free radicals may play an important role in the hemorrhagic shock in plateau, and vitamin C has obvious anti-shock effect