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目的:探讨氧自由基在高原出血性休克发生的作用及大量维生素C的抗休克作用。方法:16只山羊减压至模拟4000m高原24h,然后放血引起休克,将动物分为对照组和维生素C治疗组。结果:(1)失血期注入少量生理盐水后休克进一步加重;相反,注入维生素C后,心指数、左室收缩压、dp/dtmax、氧运送量、氧耗量和pH明显增加,而脂质过氧化物(LPO)明显降低。(2)输血输液后,对照组仅短暂改善心血管功能,其后血压下降,动物存活时间仅7h38min。而维生素C治疗组,较好保持心血管功能、LPO含量正常,活存时间为20h9min。结论:氧自由基可能在高原出血性休克发生中起着重要作用,维生素C有明显抗休克作用
Objective: To investigate the role of oxygen free radicals in plateau hemorrhagic shock and the anti-shock effect of a large number of vitamin C. Methods: 16 goats were depressurized to simulate the 4000m plateau for 24 hours, then the animals were divided into control group and vitamin C treatment group. Results: (1) Shock was further aggravated by injection of a small amount of saline during the period of blood loss; on the contrary, cardiac index, left ventricular systolic pressure, dp / dtmax, oxygen delivery, oxygen consumption and pH were significantly increased after vitamin C injection, Peroxide (LPO) was significantly reduced. (2) After transfusion, the control group only short-lived to improve the cardiovascular function, then the blood pressure dropped, the animal survival time was only 7h38min. The vitamin C treatment group, better maintain cardiovascular function, normal LPO content, survival time of 20h9min. Conclusion: Oxygen free radicals may play an important role in the hemorrhagic shock in plateau, and vitamin C has obvious anti-shock effect