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目的：为了解大学生接种乙型肝炎疫苗的效果。方法：应用ELISA法检测接种乙肝血源疫苗的大学生，使用抗-HBs参比血清标准。结果：受检测大学生2246名中，抗-HBs阳转者1706人，阳转率为76.0％，阴性者（抗-HBs＜104mIU/L）540人，占24．0％。免疫龄2年的低浓度抗-HBs为10．7％，免疫龄3年的低浓度抗-HBs为14．3％。结论：随着免疫时间延长，接种疫苗大学生的免疫反应和低浓度的抗-HBs比例明显增加。由于大学生在校时间有限，如何开展乙肝疫苗接种工作是要解决的一个问题。
Objective: To understand the effect of hepatitis B vaccine on college students. Methods: University students vaccinated with Hepatitis B vaccine were detected by ELISA, anti-HBs reference serum standard was used. Results: Of the 2246 tested undergraduates, 1706 were positive for anti-HBs, with positive rate of 76.0% and negative rate of anti-HBs <104mIU / L, accounting for 24.0%. Low-concentration anti-HBs with 2-year immunization age was 10.7% and low-concentration anti-HBs with 3-year immunization age was 14.3%. Conclusion: With the prolongation of immunization time, the immune response of vaccinated college students and the low concentration of anti-HBs increased significantly. As college students have limited time in school, how to carry out hepatitis B vaccination work is an issue to be solved.