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中科院生物物理研究所刘光慧实验室与国内外科学家合作,利用多能干细胞定向分化技术、基因组靶向编辑技术以及表观遗传组分析技术,首次揭示了异染色质的高级结构失序是人类干细胞衰老的驱动力之一,为延缓衰老及研究和防治衰老相关疾病提供了新的潜在靶点和思路。相关成果日前发表于《科学》杂志。人类衰老的过程漫长且复杂,其转化医学研究一直面临着巨大的挑战。成年早衰症是一种罕见的常染色体隐性遗传病,是由WRN基因(编
Institute of Biophysics, Chinese Academy of Sciences, Liu Guanghui laboratory and scientists at home and abroad, the use of pluripotent stem cell-directed differentiation technology, genome-targeted editing technology and epigenetic group analysis technology, revealed for the first time the high-level structural disorder of heterochromatin is the aging of human stem cells One of the driving forces for the aging and research and prevention and treatment of aging-related diseases provides a new potential targets and ideas. Related results recently published in “Science” magazine. The long and complex process of human aging has faced enormous challenges in translational medicine research. Aging premature senility is a rare autosomal recessive disease that is caused by the WRN gene (ed