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目的探讨系统性红斑狼疮(SLE)并发侵袭性真菌病(IFD)的临床特征。方法对2009年1月-2013年12月在本科住院的803例SLE患者临床资料进行分析,比较合并IFD与未合并IFD患者的临床特点。结果 SLE并发IFD者27例,没有确诊的病例;从27例IFD患者中分离到33株真菌,其中白念珠菌30株(90.91%)、光滑念珠菌2株、克柔念珠菌1株,标本分别来源于下呼吸道、消化道和泌尿道;抗真菌治疗均有效。疑似感染症状,SLEDAI≥9,CRP≥0.8mg/d L为SLE合并IFD的独立危险因素。结论本科SLE并发IFD的患者发生率为3.36%,致病菌以白念珠菌为主,氟康唑是有效的抗真菌治疗药物之一。
Objective To investigate the clinical features of systemic lupus erythematosus (SLE) complicated with invasive fungal disease (IFD). Methods The clinical data of 803 SLE patients hospitalized in our hospital from January 2009 to December 2013 were analyzed to compare the clinical features of patients with and without IFD. Results Twenty-seven cases of SLE complicated by IFD were diagnosed. There were 33 strains of Candida isolated from 27 IFD patients, including 30 Candida albicans (90.91%), 2 Candida glabrata, 1 Candida krusei, Respectively from the lower respiratory tract, digestive tract and urinary tract; antifungal therapy are effective. Symptoms of suspected infection, SLEDAI ≥ 9, CRP ≥ 0.8mg / d L SLE IFD with independent risk factors. Conclusions The incidence of undergraduate SLE with IFD is 3.36%. Candida albicans is the main pathogenic bacteria, and fluconazole is one of the effective antifungal agents.